The only caveat with taking expired drugs in general, is as one would expect, they lose their effectiveness over time. This is not necessarily going to be in a predictable fashion (ie it'll depend on storage conditions etc). Jesus, Oxy, Percocet, and Vicodin are not going to suck you into a raging addiction with one freaking pill, or likely even 6 a day for a week, unless you're very easily addicted to things, although that high dosage for a week could result in slight withdrawl symptoms. A notable issue with expired medicines is reduced efficacy, but some, like the antibiotic tetracycline, can degrade into toxic chemicals. Hospitals and pharmacies are required to toss expired drugs, no matter how expensive, vital or scarce. And that's even though the FDA has long known that many remain safe and potent for years longer. Technically, they are toxic, depending on dose. If you've ever seen anyone take too much, you quickly realize this. And, addiction is an expression of that toxicity. Hi StrepGirl, I must agree with DzooBaby on this. However, if your Oxycodone pills were NOT stored in a humid area go ahead, if they were stored in a humid place, like the bathroom, you may want to toss them. expired percocet Hi All, I have a quick question and would like to get a straight answer.I'm wondering when Percocet,Vycodin(sp?)etc go past their expiration date do they get weaker ? Human Resources for the University of Oklahoma. Serving Faculty and Staff in Norman, Oklahoma City, and Tulsa campuses. Do expired drugs lose their potency? Is it safe to take expired medications? Find out with this comprehensive guide about drug expiration dates by Drugs.com Percocet is not oxycodone First, the expiration date, required by law in the United States, beginning in 1979, specifies only the date the manufacturer guarantees the full potency and safety of the drug -- it does not mean how long the drug is actually good or safe to use.